Publications by authors named "L R Athira Krishnan"
Autologous platelet-rich fibrin (PRF) therapy is beneficial in the treatment of nonhealing ulcers. We present a case series of nonhealing, trophic ulcers with underlying leprous neuropathy, treated successfully with PRF therapy. It was a prospective study, conducted in a tertiary care hospital in the western Maharashtra, India between April 2021 and March 2022.
View Article and Find Full Text PDFHigh-frequency ultrasonography for the detection of subclinical arthritis in chronic plaque psoriasis patients - A cross-sectional study.
Indian J Dermatol Venereol Leprol
September 2024
Article Synopsis
- Psoriatic arthritis (PsA) often develops in patients with psoriasis, and early detection is crucial for better outcomes, making screening essential.
- A study conducted at Armed Forces Medical College examined 117 chronic plaque psoriasis patients without visible arthritis using high-frequency ultrasound, revealing common issues like synovial thickening in the distal interphalangeal joint and Achilles tendon.
- While the study shows the effectiveness of ultrasound in identifying subclinical PsA, its cross-sectional design and lack of matched controls highlight the need for future longitudinal studies for more comprehensive understanding and validation.
This study employed a ligand-based pharmacophoric approach to design and synthesize 33 novel semisynthetic labdane-appended triazolyl isatins to discover potential anti-inflammatory agents. The anti-inflammatory efficacy of the derivatives was evaluated by their ability to inhibit the production of NO, TNF-α, and IL-6, in lipopolysaccharide-induced RAW264.7 macrophages.
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