Involvement of receptor-bound protein methyltransferase PRMT1 in antiviral and antiproliferative effects of type I interferons.

Protein arginine N-methyltransferase (PRMT1) is one of the proteins that bind to the intracytoplasmatic domain of the IFNAR-1 chain of the type I interferon (IFN) receptor system. The attachment is specific and is not seen with PRMT2, another member of this protein family. Antisense PRMT1 cDNA constructs expressed under the early cytomegalovirus (CMV) promoter were transfected into HeLa cells, and stable transformants were selected.

Positron-emission tomography in tardive dyskinesia.

Cerebral glucose metabolic rates were determined in normal control subjects (n = 26) and schizophrenic patients with tardive dyskinesia (n = 14). Globus pallidus and primary motor cortex (precentral gyrus) metabolic values divided by those of the cerebral hemispheres were significantly increased in the patient group. A similar metabolic pattern has not been reported for schizophrenic patients without tardive dyskinesia, and the abnormalities were demonstrated despite the normal appearance of the basal ganglia on X-ray CT.

Epidermal growth factor stimulates thyrotropin secretion in the rat.

The present work studied the effects of epidermal growth factor (EGF) on the release of thyrotropin (TSH) and prolactin (PRL) from perifused pituitary glands of 200-gram male Wistar rats. Each pituitary gland, cut into halves, was placed in a chamber of a perifusion system connected to a peristaltic pump which conveyed the perifusion medium (Medium 199, pH 7.3, Gibco, USA) from a reservoir to a chamber at a flow rate of 100 microliters/min.

[The effect of epidermal growth factor on thyrotropin secretion in rats].

The present work studied the effects of epidermal growth factor (EGF) on the secretion of thyrotropin (TSH) from perifused pituitaries of 200 g body weight male Wistar rats. After decapitation the neural lobe was discarded and the anterior pituitary was transferred to a chamber of a perifusion system connected to a peristaltic pump which conveyed the perifusion medium (Medium 199) through a reservoir to a chamber at a flow rate of 100 microliters/min. Individual chambers were filled with 600 microliters of medium and placed in a water bath at 37 degrees C.

[Effects of cold on myocardial mitochondria respiration of rats with hypothyroidism treated with triiodothyronine].

The present work studied the effect of cold on oxygen consumption (OC) and alpha-glycerophosphate dehydrogenase activity (alpha-GPD) in heart mitochondria of hypothyroid rats (hypo) treated with T3, T4 or T4 plus Iopanoic Acid (IOP). 200 g male Wistar rats were made hypothyroid by 131I administration. Animals were injected s.