cfDNA hydroxymethylcytosine profiling for detection metastasis and recurrence of Esophageal Squamous Cell Carcinoma.

Background: A blood-based approach to monitor metastasis and recurrence of esophageal squamous cell carcinoma (ESCC) remains undeveloped. This study aimed to establish a dependable model utilizing cfDNA 5-hydroxymethylcytosines (5hmC) signatures to detect these conditions in ESCC.

Methods: The 5hmC-Seal technique was employed to generate comprehensive 5hmC profiles from the plasma cell-free DNA (cfDNA) of 122 ESCC patients, classified into 72 with metastasis, 50 without metastasis, 30 with recurrence, and 92 without recurrence.

Double balloon catheter induction of labor in pregnant women with COVID-19 infection.

Background: To identify the effectiveness and safety induction using a double-balloon catheter in the setting of Coronavirus disease 2019 (COVID-19) infection.

Methods: This retrospective study included 577 COVID-19-afected women who underwent induction of labor with a double balloon catheter or spontaneously started delivery between December 7, 2022, and June 20, 2023; 154 women underwent induction of labor (double balloon catheter, study group) and 423 women underwent spontaneous started delivery (control group). Maternal and neonatal outcomes and complications during labor were assessed and compared.

Super-multiplexed imaging and coding in the range of radio frequency.

The era of the Internet has led to an information explosion, creating significant challenges for current techniques in information storage and access. High-performance strategies that expand existing methods offer a promising solution. Imaging-based approaches are vital for information perception but remain underexplored for information processing due to limited multiplexity.

Adipose Mesenchymal Stem Cell Exosomes Regulate Ferroptosis via ATF3 to Attenuate Acute Myocardial Infarction.

Objective: During acute myocardial infarction (AMI), ferroptosis occurs in cardiomyocytes, leading to ventricular remodeling. To investigate the influence of exosomes (Exo) derived from adipose mesenchymal stem cells (AD-MSCs) on cardiomyocytes, a therapeutic approach to resolve AMI may be discovered.

Methods: The Exo of AD-MSCs was isolated and identified, and internalized into cardiomyocytes.

Oral ADC189 for Adults and Adolescents with Uncomplicated Influenza.

Objectives: ADC189 is a novel anti-influenza virus inhibitor. In this study, we aimed to evaluated the safety and efficacy of ADC189 in outpatients with uncomplicated influenza infection.

Methods: In the phase 2 trial, we assigned patients in a 2:2:1 ratio to receive either single dose 15-mg or 45-mg of ADC189 or placebo.