Publications by authors named "L Q Ai"
High glucose induces pro-inflammatory polarization of macrophages by inhibiting immune-responsive gene 1 expression.
Nan Fang Yi Ke Da Xue Xue Bao
January 2025
Objectives: To investigate the effect of high glucose on macrophage polarization and the role of immune-responsive gene 1 (IRG1) in mediating its effect.
Methods: RAW264.7 cells were transfected with IRG1-overexpressing plasmid or IRG1 siRNA via electroporation and cultured in either normal or high glucose for 72 h to observe the changes in cell viability and morphology using CCK-8 assay and phase contrast microscopy.
Defect engineering is considered one of the most powerful strategies for regulating the catalytic activity of electrocatalysts. A deep understanding of the defect-involved mechanism in electrocatalytic process is of great importance but remains a challenging task. In this study, an anionic Se-vacancy (V) was introduced into iron diselenide (FeSe) nanoarrays, enabling the catalyst to exhibit improved electrocatalytic performance for sulfion oxidation reaction (SOR).
View Article and Find Full Text PDFArticle Synopsis
- Researchers have developed targeted covalent nanodrugs that improve the delivery and effectiveness of small-molecule chemotherapeutics, overcoming challenges in drug accumulation in tumors.
- The nanodrugs utilize near-infrared (NIR) irradiation to activate and bind to specific cancer cell receptors, significantly increasing the accumulation of the drug doxorubicin within tumors compared to standard methods.
- These advancements lead to enhanced cancer treatment outcomes, boosting the immune response and reducing tumor size while also minimizing side effects compared to traditional treatments.
The developmental competence and epigenetic progression of oocytes gradually become dysregulated with increasing maternal age. However, the mechanisms underlying age-related epigenetic regulation in oocytes remain poorly understood. Zygote arrest proteins 1 and 2 (ZAR1/2) are two maternal factors with partially redundant roles in maintaining oocyte quality, mainly known by regulating mRNA stability.
View Article and Find Full Text PDFBackground: Pembrolizumab with/without platinum + 5-FU is approved for the first-line (1L) treatment of R/M HNSCC, and its monotherapy use requires PD-L1 Combined Positive Score (CPS) ≥ 1. We aimed to understand PD-L1 testing patterns and associations with patient characteristics and treatment choice in R/M HNSCC.
Methods: Adults with R/M HNSCC initiating 1L systemic therapy were included from a U.