Publications by authors named "L Puscasiu"
Endometriosis is a benign disease but with malignant behavior, sharing numerous features with cancers. Endometriosis is the development of endometrial tissue outside the uterus, with the presence of both glands and stroma. Approximately 10% of women of reproductive age suffer from endometriosis; it involves high social costs and affects the patient's quality of life.
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- The study investigates pregnancy-related infections among hospitalized women in 52 countries, analyzing clinical and microbiological characteristics, as well as antibiotic use based on infection sources and economic status.
- Among the 1,456 women studied, genital infections (51.2%) and urinary tract infections (36.5%) were the most common, with Escherichia coli identified as the major uropathogen.
- Significant delays in antibiotic administration were noted, with cephalosporins being the most frequently used for urinary tract infections, while metronidazole was predominant in lower-income countries.
Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis.
View Article and Find Full Text PDFCongenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing.
View Article and Find Full Text PDFObjective: We evaluated clinicopathologic parameters of patients with cervical squamous cell carcinoma (SCC) who were treated with initial surgical management and assessed their relation to survival outcomes. Specifically, we evaluated the relation between extent of lymphovascular invasion (LVI) and survival outcomes.
Methods: All available tumor slides from patients with initially surgically treated cervical SCC were collected from 10 institutions and retrospectively analyzed.