Publications by authors named "L Pulaski"
Article Synopsis
- The study investigates the effects of Bisphenol A (BPA) and Tetrabromobisphenol A (TBBPA) on the dynamics of biological membranes, focusing on how these persistent organic pollutants impact myeloid cell lines.
- It was found that TBBPA specifically disrupts the plasma membrane's biophysical homeostasis, increasing mobility and decreasing order, while BPA showed no significant effects.
- The findings highlight TBBPA's potential to impair immune function, emphasizing the environmental toxicity concerns associated with persistent organic pollutants.
Astrocytes play an important role in the regulation of the inflammatory response in the CNS, e.g., in demyelinating diseases.
View Article and Find Full Text PDFFlame retardants (FRs) are chemical substances used to inhibit the spread of fire in numerous industrial applications, and their abundance in modern manufactured products in the indoor and outdoor environment leads to extensive direct and food chain exposure of humans. Although once considered relatively non-toxic, FRs are demonstrated by recent literature to have disruptive effects on many biological processes, including signaling pathways, genome stability, reproduction, and immune system function. This review provides a summary of research investigating the impact of major groups of FRs, including halogenated and organophosphorus FRs, on animals and humans in vitro and/or in vivo.
View Article and Find Full Text PDFArticle Synopsis
- Mesalazine is a key medication for inflammatory bowel diseases, but its effectiveness is limited by rapid breakdown and transport challenges, prompting the development of a new nanocarrier using PAMAM dendrimers to enhance drug delivery to intestinal cells.
- The study successfully synthesized a PAMAM-mesalazine conjugate, confirming its purity, and demonstrated that approximately 45 mesalazine molecules were attached to each dendrimer, improving drug characteristics for cellular uptake.
- The use of this dendrimer-based delivery system significantly enhances the bioavailability and anti-inflammatory effectiveness of mesalazine in vitro, potentially bypassing the need for specific transporters.
Article Synopsis
- Nonprocessed plant foods, particularly whole-grain cereals, are recognized for their health benefits, largely due to their fiber content and low glycemic index, as well as the recently acknowledged role of phenolic phytonutrients.
- A key focus of this review is on 3,5-dihydroxybenzoic acid (3,5-DHBA), found in foods like apples and derived from whole grains, which acts as an agonist for the HCAR1/GPR81 receptor, influencing various biological processes.
- The paper emphasizes the significance of understanding how 3,5-DHBA affects cancer growth and treatment responses, highlighting the need for further research on its implications in both health and disease management in humans.