Publications by authors named "L Pugni"
Article Synopsis
- ! Antibiotics are given to 20%-30% of pregnant women, yet their impact on newborn immune development is not well understood, leading to increased susceptibility to sepsis in offspring of treated mothers.
- ! Newborn mice from antibiotic-treated mothers showed lower levels of immunoglobulin A (IgA) in breast milk and feces, leading to a weakened gut immune response and increased risks of gut bacteria entering the bloodstream.
- ! Restoring IgA production through treatments or using breast milk from untreated mothers improved immune profiles and offered protection against sepsis in pups, emphasizing the importance of breastfeeding in mitigating antibiotic effects.
Article Synopsis
- The study investigates the reasons behind the increased reactivity of T cells in newborns, focusing on specific molecular mechanisms that are not well understood.
- It identifies that neonatal naïve T cells produce more energy and proteins, linked to the lack of LINE1 expression due to specific signaling pathways.
- LINE1 expression increases with age, affecting T cell function and contributing to immune decline as people get older, suggesting its importance throughout human development.
Sudden infant death syndrome (SIDS) "gray zone" or borderline cases are those in which it is challenging to define whether the pathological findings are sufficiently severe to lead to death. We report a case of a 17-day old male newborn who came to our attention for unexplained death. A complete autopsy was performed, including close examination of the cardiac conduction system.
View Article and Find Full Text PDFBackground: Antenatal universal screening for toxoplasmosis is recommended in most affluent countries worldwide. Despite evidence is not robust, detected cases are typically treated during pregnancy. Affected newborns are also treated to temper clinical consequences.
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