Publications by authors named "L Puget"
Cervical cancer screening is a cornerstone of cervical cancer elimination. Detection of high-risk human papillomavirus (hrHPV) is recommended as the first step in screening provided that the assay used has been adequately validated. The Sansure® Human Papillomavirus DNA Diagnostic Kit is a new assay designed to detect HPV16, HPV18 and 13 other HPV in aggregate.
View Article and Find Full Text PDFCytomegalovirus (CMV) excretion in urine is frequently observed in clinical practice. However, the specific circumstances and pathophysiological mechanisms underlying this shedding remain largely unknown. Here, we address some of the key questions regarding urinary CMV excretion, focusing on new hypotheses raised by recent advances in the field.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the "gray-zone" of HPV test results in cervical cancer screening, where test sensitivity and clinical thresholds vary.
- Over a 22-month period, 1.7% of HPV results from over 6,100 samples fell into this gray-zone, with higher prevalence in certain HPV genotypes.
- Most gray-zone results showed no significant cytological abnormalities, but a small number of patients with a history of persistent HPV should be monitored closely due to potential risks.
Background: Detection of high-risk human papillomaviruses (hrHPV) is widely used at the first line of cervical cancer screening, requiring rigorous validation of the clinical performance of commercial kits designed for this indication.
Methods: Performance of the AmpFire HPV Screening 16/18/HR test (AF, Atila Biosystems) and the Hybrid Capture 2 test (HC2, Qiagen) for detecting hrHPV was cross-compared in 200 cervical samples in our institution.
Results: The global percentage of agreement between the 2 techniques was 95.
Background: Episodes of CMV-viruria have been reported in hematopoietic stem cell transplant (HSCT) recipients, but their context of occurrence, pathophysiology, and clinical significance remain misunderstood.
Methods: Uurine samples from 517 recipients were collected. Clinical features of recipients with or without episodes of CMV-viruria were retrospectively compared.