Antagonistic effect of low deprenyl dose on the preimplantation embryo development in rat.

To investigate the role of potent MAO-B inhibitor deprenyl in fertilized females, we have evaluated the effect of chronic treatment with deprenyl at a low dosage on preimplantation embryo development in Wistar rats. We have found that the number of isolated embryos per rat did not differ between experimental and control groups. But morphological analysis of embryos isolated from deprenyl-treated animals had revealed improved rates in the distribution pattern compared with controls.

Gp96 and its different expression in breast carcinomas.

The aim of our work was to determine the expression of glycoprotein 96 (gp96; glucose-regulated protein 94 - GRP94) in 69 samples of breast carcinoma. Enzyme immunohistochemical method was chosen for the detection of gp96 protein and its expression was compared in breast cancer cells versus normal breast cells. We found higher expression of gp96 protein in breast carcinoma cells and low or no expression in normal breast cells.