An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL.

Chimeric antigen receptor T cell (CAR T) therapy is a potent treatment for relapsed/refractory (r/r) B cell lymphomas but provides lasting remissions in only ∼40% of patients and is associated with serious adverse events. We identify an upregulation of CD80 and/or CD86 in tumor tissue of (r/r) diffuse large B cell lymphoma (DLBCL) patients treated with tisagenlecleucel. This finding leads to the development of the CAR/CCR (chimeric checkpoint receptor) design, which consists of a CD19-specific first-generation CAR co-expressed with a recombinant CTLA-4-linked receptor with a 4-1BB co-stimulatory domain.

A Systematic Literature Review of Virtual Reality Locomotion Taxonomies.

The change of the user's viewpoint in an immersive virtual environment, called locomotion, is one of the key components in a virtual reality interface. Effects of locomotion, such as simulator sickness or disorientation, depend on the specific design of the locomotion method and can influence the task performance as well as the overall acceptance of the virtual reality system. Thus, it is important that a locomotion method achieves the intended effects.

Emotions are associated with the genesis of visually induced motion sickness in virtual reality.

Visually induced motion sickness (VIMS) is a well-known side effect of virtual reality (VR) immersion, with symptoms including nausea, disorientation, and oculomotor discomfort. Previous studies have shown that pleasant music, odor, and taste can mitigate VIMS symptomatology, but the mechanism by which this occurs remains unclear. We predicted that positive emotions influence the VIMS-reducing effects.

Outcome in patients with left common pulmonary vein after cryoablation with second-generation cryoballoon.

Background: Pulmonary vein isolation (PVI) has become a widely accepted therapy in patients suffering from symptomatic atrial fibrillation (AF).

Hypothesis: AF-free survival differs in patients with left common pulmonary vein (LCPV) after PVI with second-generation cryoballoon.

Methods: We included patients scheduled for first PVI for paroxysmal or persistent AF.