Publications by authors named "L Priest"
Article Synopsis
- * It involves 140 participants aged 60 and older with untreated OSA, randomizing them into two groups: one receiving CPAP along with usual care for fall prevention, and the other receiving only the usual care.
- * The study will assess various outcomes including fall risk scores, gait, and overall health, with results intended for publication and future guidelines on fall prevention in older adults.
Molecular subtypes of Small Cell Lung Cancer (SCLC) have been described based on differential expression of transcription factors (TFs) , and immune-related genes. We previously reported an additional subtype based on expression of the neurogenic TF within our SCLC Circulating tumour cell-Derived eXplant (CDX) model biobank. Here we show that ATOH1 protein was detected in 7/81 preclinical models and 16/102 clinical samples of SCLC.
View Article and Find Full Text PDFLung cancer is the leading cause of cancer deaths. Its high mortality is associated with high metastatic potential. Here, we show that the RAC1-selective guanine nucleotide exchange factor T cell invasion and metastasis-inducing protein 1 (TIAM1) promotes cell migration and invasion in the most common subtype of lung cancer, non-small-cell lung cancer (NSCLC), through an unexpected nuclear function.
View Article and Find Full Text PDFArticle Synopsis
- Vasculogenic mimicry (VM) is a process in which tumor cells acquire endothelial-like traits to form new blood vessels, linked to a poor prognosis in small cell lung cancer (SCLC) and requiring cooperation between neuroendocrine (NE) and non-NE cells for metastasis.
- Through the use of advanced models and patient samples, the study identifies VM vessels in most analyzed cases, confirming their role in supporting tumor growth and highlighting the importance of NOTCH-active non-NE cells in this process.
- The findings emphasize the functional diversity and adaptability in SCLC, suggesting that targeting both NE and non-NE cells could lead to better treatment outcomes for patients with this cancer type.