Publications by authors named "L Pretsch"
The objective of this study was to develop two lipid nanoparticle (LNP) formulations capable of efficiently expressing a reporter mRNA while co-delivering the anti-inflammatory drug dexamethasone (DX) to reduce inflammatory side effects in protein replacement therapies. Two types of LNPs were developed, in which 25% of cholesterol was replaced by DX. These LNPs contained either 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) as a helper lipid.
View Article and Find Full Text PDFLipid nanoparticles (LNPs) tailored for mRNA delivery were optimized to serve as a platform for treating metabolic diseases. Four distinct lipid mixes (LMs) were formulated by modifying various components: LM1 (ALC-0315/DSPC/Cholesterol/ALC-0159), LM2 (ALC-0315/DOPE/Cholesterol/ALC-0159), LM3 (ALC-0315/DSPC/Cholesterol/DMG-PEG2k), and LM4 (DLin-MC3-DMA/DSPC/Cholesterol/ALC-0159). LNPs exhibited stability and homogeneity with a mean size of 75 to 90 nm, confirmed by cryo-TEM and SAXS studies.
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- Acute febrile diseases from mosquitos pose diagnostic challenges for pediatricians in sub-Saharan Africa, leading to misclassification and inappropriate use of antibiotics and antimalarials.
- A study in Tanzania analyzed the efficacy of blood smear microscopy and rapid malaria diagnostic tests compared to a more accurate PCR-ELISA method.
- The findings revealed that rapid diagnostic tests had higher sensitivity and specificity, significantly reducing unnecessary antimalarial prescriptions in malaria-negative patients, thereby addressing issues of drug resistance.
Article Synopsis
- Acoustic metamaterials use arrangements of meta-atoms for applications like acoustic cloaking and sound focusing, requiring precise design and understanding of their interactions for optimal performance.
- Adjusting the coupling and tuning of individual meta-atoms can enhance features like sound attenuation by mitigating destructive interference in their scattered fields.
- Numerical simulations and experimental studies demonstrate that factors like separation, orientation, and radiation loss of resonators significantly impact their coupling and enhance sound attenuation capabilities.
Childhood mortality represents a major issue with 5. 3 million worldwide deaths of children under 5 years of age in 2019. Approximately half of those deaths can be attributed to easily preventable, infectious diseases.
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