Publications by authors named "L Prado"
Article Synopsis
- Runners who don't allow enough recovery time after training may be at a higher risk for injuries due to fatigue and altered movement patterns.
- A study looked at how different running intensities affect lower-limb joint movements and coordination during a single-leg squat in 30 healthy runners.
- Immediate and longer-term changes showed that coordination patterns became less adaptive (more regular) after moderate and high-intensity runs, but traditional kinematic analysis did not effectively capture these changes.
This review aims to summarize recent research using animal models, cell models, and human data regarding the role of complement in liver disease. Complement is part of the innate immune system and was initially characterized for its role in control of pathogens. However, evidence now indicates that complement also plays an important role in the response to cellular injury that is independent of pathogens.
View Article and Find Full Text PDFThe association of ABC proteins with multidrug resistance in cancer.
Andrezza Viviany Lourenço Marques Bruna Estelita Ruginsk Larissa de Oliveira Prado Diogo Eugênio de Lima Isabelle Watanabe Daniel
Biochim Biophys Acta Mol Cell Res
February 2025
Article Synopsis
- Multidrug resistance (MDR) in cancer treatment, particularly for metastatic disease, is largely driven by the overexpression of ATP-binding cassette (ABC) proteins.
- A total of 20 ABC proteins were identified as associated with MDR, highlighting the importance of drug transport and sequestration within cells.
- The study emphasizes the need for further research to understand MDR mechanisms better and improve pharmacological approaches for more effective cancer treatments.
Article Synopsis
- Deficiencies in the electron transport chain (ETC) contribute to mitochondrial diseases, but the reasons for different cellular sensitivities to this disruption are not fully understood.
- This study finds that under ETC inhibition, a different type of tricarboxylic acid (TCA) cycle is activated to maintain malate levels and produce NADPH, which is crucial for cell function.
- The research highlights how astrocytes, which express specific enzymes like Pyruvate carboxylase (PC) and ME1 more than neurons, demonstrate greater resilience to ETC issues, suggesting potential therapeutic strategies for managing mitochondrial diseases.
We provide updated diagnoses for the senex-, burtoni- and dimorphus-groups of Camponotus (Myrmobrachys). Dichotomous keys for the C. (Myrmobrachys) groups and species of the dimorphus-group, based on type-specimens are provided.
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