Postprandial metabolomics analysis reveals disordered serotonin metabolism in post-bariatric hypoglycemia.

BACKGROUNDBariatric surgery is a potent therapeutic approach for obesity and type 2 diabetes but can be complicated by post-bariatric hypoglycemia (PBH). PBH typically occurs 1-3 hours after meals, in association with exaggerated postprandial levels of incretins and insulin.METHODSTo identify mediators of disordered metabolism in PBH, we analyzed the plasma metabolome in the fasting state and 30 and 120 minutes after mixed meal in 3 groups: PBH (n = 13), asymptomatic post-Roux-en-Y gastric bypass (post-RYGB) (n = 10), and nonsurgical controls (n = 8).

The health and economic burden of breathlessness, Australia, 2019: a national survey.

Objective: To examine the impact of breathlessness on quality of life, health care use, productivity loss, and economic costs in Australia.

Study Design: National internet-based survey of Australian adults drawn from a web-based survey panel (National Breathlessness Survey).

Participants, Setting: Australian adults (18 years or older), nationally representative by age group, gender, state of residence, and postcode-based socio-economic status (Index of Relative Socioeconomic Disadvantage quintile), 13-30 October 2019.

Prevalence and burden of difficult-to-treat and severe asthma in Australia: A national population survey.

Background And Objective: Most evidence about difficult-to-treat and severe asthma (DTTA) comes from clinical trials and registries. We aimed to identify people with DTTA from a large nationally representative asthma population and describe their characteristics and healthcare utilization compared with people whose asthma was not 'difficult-to-treat'.

Methods: We conducted a cross-sectional survey of Australians aged ≥18 years with current asthma from large web-based survey panels.

Contribution of obesity to breathlessness in a large nationally representative sample of Australian adults.

Background And Objective: Breathlessness is prevalent and associated with medical consequences. Obesity is related to breathlessness. However, the magnitude of its contribution has not been clearly documented.

Qualitative validation of the modified Medical Research Council (mMRC) dyspnoea scale as a patient-reported measure of breathlessness severity.

Introduction: The modified Medical Research Council (mMRC) dyspnoea scale is a measure of breathlessness severity recommended by guidelines and utilised as an inclusion criterion or endpoint for clinical trials. No studies have been conducted to validate the categorical descriptors against the dyspnoea severity grade.

Methods: This study utilised cognitive interviews (Think Aloud method) to assess the content validity of the mMRC scale among 16 participants (13 with cardiac/respiratory disease).