Publications by authors named "L Potena"
Background: Coronary computed tomography angiography (CCTA) is emerging as a valuable tool for noninvasive surveillance of cardiac allograft vasculopathy (CAV) in patients with heart transplant (HTx). We assessed the diagnostic performance of a comprehensive CCTA-based approach compared with the invasive reference, which includes invasive coronary angiography, intravascular ultrasound, and fractional flow reserve, for detecting CAV.
Methods: This was a multicenter prospective study including 37 patients with HTx who underwent CCTA, invasive coronary angiography, intravascular ultrasound, and fractional flow reserve.
Article Synopsis
- - Diagnosing cardiac sarcoidosis (CS) is difficult, often leading to heart transplantation (HT) as the last option, especially when immunosuppressive therapies fail in advanced cases.
- - The case study presents four patients, each with different symptoms and backgrounds, who ultimately required HT for their CS, revealing the condition's complexity and urgency.
- - There are significant mid- and long-term challenges following HT for CS, notably the need for careful management of immunosuppression to prevent rejection and recurrence of sarcoidosis.
Resource utilization and healthcare management of invasive versus non-invasive strategy for cardiac allograft vasculopathy surveillance in heart transplantation.
J Cardiovasc Comput Tomogr
November 2024
The field of organ transplantation is experiencing a transformative shift with the rise of Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption is hindered by complex regulatory frameworks, high production costs, and inconsistent access across Europe.
View Article and Find Full Text PDF