Publications by authors named "L Poluektova"
Article Synopsis
- Neurosurgeries complicated by infection lead to longer treatment times and serious health issues, especially in craniotomies, but the specific cellular and molecular factors involved are unclear.
- A study of over 2,500 craniotomy cases shows variations in patient backgrounds, types of infections, and surgical details linked to infections.
- Analysis reveals that a type of immune cell called granulocytic myeloid-derived suppressor cells dominates the infection response, and metabolic changes in these cells may indicate potential targets for new therapies against craniotomy infections in light of rising drug resistance.
Accelerated Neuroimmune Dysfunction in Aged HIV-1-Infected Humanized Mice.
Pharmaceuticals (Basel)
January 2024
Disordered immunity, aging, human immunodeficiency virus type one (HIV-1) infection, and responses to antiretroviral therapy are linked. However, how each factor is linked with the other(s) remains incompletely understood. It has been reported that accelerated aging, advanced HIV-1 infection, inflammation, and host genetic factors are associated with host cellular, mitochondrial, and metabolic alterations.
View Article and Find Full Text PDFChronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence.
View Article and Find Full Text PDFBackground: Hepatitis B virus (HBV) infection develops as an acute or chronic liver disease, which progresses from steatosis, hepatitis, and fibrosis to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). An increased stromal stiffness accompanies fibrosis in chronic liver diseases and is considered a strong predictor for disease progression. The goal of this study was to establish the mechanisms by which enhanced liver stiffness regulates HBV infectivity in the fibrotic liver tissue.
View Article and Find Full Text PDFLong-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported here. Pharmacokinetics over 28 days were assessed in Wistar rats, New Zealand white rabbits, and Balb/C mice following intramuscular injection.
View Article and Find Full Text PDF