Publications by authors named "L Polo"
: Failure mode and effect analysis (FMEA) is a valuable risk analysis tool aimed at predicting the potential failures of a system and preventing them from occurring. Since its initial use, it has also recently been applied to the healthcare setting, which has been made progressively more complex by technological developments and new challenges. Infection prevention and control (IPC) is an area that requires effective strategies.
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- The study highlights challenges in diagnosing sarcopenia among hemodialysis patients due to differing definitions from the EWGSOP2 and SDOC consensuses.
- Similar prevalence rates for sarcopenia were found using both definitions, but there was a weak overall agreement in diagnoses between the two methods.
- The results suggest that while there is some alignment in identifying severe sarcopenia cases, the discrepancies in diagnosing low muscle strength indicate a need for standardized approaches in clinical settings.
Objectives: The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers in individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential for combining international experience with paediatric VADs.
View Article and Find Full Text PDFBotulinum neurotoxins (BoNTs) are valuable tools to unveil molecular mechanisms of exocytosis in neuronal and non-neuronal cells due to their peptidase activity on exocytic isoforms of SNARE proteins. They are produced by Clostridia as single-chain polypeptides that are proteolytically cleaved into light, catalytic domains covalently linked via disulfide bonds to heavy, targeting domains. This format of two subunits linked by disulfide bonds is required for the full neurotoxicity of BoNTs.
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