Publications by authors named "L Platon"
Article Synopsis
- The study aimed to analyze the characteristics and outcomes of critically ill patients with severe pneumonia caused by SARS-CoV-2 across different pandemic waves, focusing on morbidity and mortality predictors.
- Conducted from March 2020 to October 2021, the study included 437 adult patients and found that ICU mortality decreased from 26% in the first wave to around 10% in later waves, with factors like age and comorbidities influencing death risk.
- The research concluded that overall survival improved due to the effects of interventions like vaccination and dexamethasone, although bronchopulmonary aspergillosis increased mortality risk significantly to 36%.
Outcomes in Critically Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients.
Am J Respir Crit Care Med
October 2024
Article Synopsis
- A study examined the mortality and factors affecting outcomes for 1,164 patients who underwent allogeneic hematopoietic stem-cell transplantation and were admitted to ICUs in France from 2015 to 2020.
- The findings revealed a 90-day mortality rate of 48%, with higher risks linked to age, time from transplant to ICU admission, and the need for invasive treatments like vasopressors and mechanical ventilation.
- Despite high mortality rates, many critically ill patients who received intensive care did survive their ICU stays, prompting the need for a careful evaluation of treatment options for those with multiple risk factors.
During blood-stage infection, parasites are constantly exposed to a range of extracellular stimuli, including host molecules and drugs such as artemisinin derivatives, the mainstay of artemisinin-based combination therapies currently used as first-line treatment worldwide. Partial resistance of to artemisinin has been associated with mutations in the propeller domain of the gene, resulting in a fraction of ring stages that are able to survive exposure to artemisinin through a temporary growth arrest. Here, we investigated whether the growth arrest in ring-stage parasites reflects a general response to stress.
View Article and Find Full Text PDFMalaria is a life-threatening tropical disease caused by parasites of the genus Plasmodium, of which Plasmodium falciparum is the most lethal. Malaria parasites have a complex life cycle, with stages occurring in both the Anopheles mosquito vector and human host. Ring stages are the youngest form of the parasite in the intraerythrocytic developmental cycle and are associated with evasion of spleen clearance, temporary growth arrest (TGA), and drug resistance.
View Article and Find Full Text PDFArticle Synopsis
- Tubular injury is identified as the primary cause of acute kidney injury (AKI) in critically ill patients with COVID-19, with proximal tubular dysfunction (PTD) and specific urinary biomarkers potentially indicating AKI before it occurs.
- A study analyzing 60 ICU COVID-19 patients revealed that 48% had PTD, 55% developed AKI, and 33% experienced persistent AKI, with urinary NGAL being the most effective biomarker for predicting these conditions.
- The findings highlight that while PTD and AKI were common among patients, higher levels of the simplified acute physiology score (SAPSII) and certain medical treatments contributed significantly to the risk of AKI.