Crisis standards of care within the first wave of the COVID-19 pandemic.

The ability of the healthcare infrastructure to overcome overwhelming needs during a crisis or disaster with equitable care stems from the implementation of crisis standards of care (CSC). CSC provides a framework for the discussion and planning of how to adapt care to meet these needs, while focusing on the greatest good for the greatest number. The COVID-19 pandemic has challenged healthcare infrastructure, but no formal CSC declaration or disclosure to the public within the first wave of the COVID-19 pandemic leads to the need for further inquiry surrounding the planning and implementation for CSC.

Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study.

Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease whose primary clinical manifestation is bilateral visual loss. Only a single therapy, idebenone, is approved in Europe for use in exceptional circumstances and no therapy is currently approved in the USA. LHON remains a disease with a high unmet medical need.

Pulmonary embolization of iodine-125 seeds following prostate implantation.

The optimal treatment of prostatic carcinoma limited to the gland remains controversial. Treatment has included implantation of Iodine-125 seeds via both a suprapubic approach and, more recently, a transperineal technique utilizing ultrasound guidance. We recently have noted a heretofore unreported complication with this latter technique, namely, embolization of seeds to the lungs.

Solitary metastasis of renal cell carcinoma to urethra.

A case report of a solitary metastasis to the urethra from previously resected renal cell carcinoma is reported. The patient presented with total gross painless hematuria. We believe this is the first such case to be reported.

Angiosarcoma of kidney.

We describe a forty-six-year-old man who died of disseminated angiosarcoma ten months after a radical nephrectomy and postoperative radiation therapy for a renal angiosarcoma. We found 3 other well-documented reports of renal angiosarcoma, all in men. Two of the 3 cases previously reported also had a rapidly fatal course with hematogenous spread of the neoplasm following nephrectomy.