Publications by authors named "L Pitto"
Article Synopsis
- Ventricular assist devices (VADs) can help manage end-stage heart failure in children by altering molecular pathways associated with heart function, particularly focusing on microRNAs' (miRNAs) role in the adiponectin (ADPN) system.
- The study involved measuring ADPN levels in pediatric heart failure patients before and after VAD implantation and analyzing heart tissue for miRNA and ADPN system components.
- Results showed that while VAD did not change ADPN levels, it increased the expression of ADPN receptors, with certain miRNAs potentially influencing these changes, indicating miRNAs could be key therapeutic targets for improving heart function in children.
Article Synopsis
- Docetaxel (DCT) resistance significantly hinders the effectiveness of treatments for metastatic prostate cancer (PCa), and this study identifies specific miRNAs (miR-96-5p, miR-183-5p, and miR-210-3p) released by DCT-resistant PCa clones that further diminish DCT efficacy when overexpressed.* -
- The study uses bioinformatic analysis to pinpoint key targets of these sDCT-miRNAs, such as FOXO1 and IGFBP3, which are involved in DCT resistance, while highlighting that certain proteins (PPP2CB and INSIG1) facilitate the miRNAs' impact on drug effectiveness.* -
- Additionally
BRAFV600E comes as two main splicing variants. The well-studied ref isoform and the recently discovered X1 isoform are co-expressed in cancer cells and differ in terms of 3'UTR length and sequence, as well as C-term protein sequence. Here, we use a melanoma model in zebrafish to study the role played by each isoform in larval pigmentation, nevi formation, and their progression into melanoma tumours.
View Article and Find Full Text PDFMicroRNAs (miRNAs) are endogenous, evolutionarily conserved, non-coding RNA molecules that influence most, if not all biological events, with cardiovascular development and homeostasis being no exceptions [...
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