Publications by authors named "L Pisanello"
Article Synopsis
- * The revision was based on new literature from 2012 to 2018 and included evaluating risk factors for conditions like high-grade vesicoureteral reflux and renal scarring, along with group discussions when evidence was scarce.
- * Key changes include new urine collection methods, a revised decision-making algorithm for tests, updated antibiotic recommendations, and limitations on antibiotic prophylaxis, all now endorsed by relevant pediatric societies in Italy.
The SHOX gene and the short stature. Roundtable on diagnosis and treatment of short stature due to SHOX haploinsufficiency: how genetics, radiology and anthropometry can help the pediatrician in the diagnostic process Padova (April 20th, 2011).
Pediatr Endocrinol Rev
August 2012
The growth of the human body depends from a complex interaction between nutritional, environmental and hormonal factors and by a large number of different genes. One of these genes, short stature homeobox (SHOX), is believed to play a major role in growth. SHOX haploinsufficiency is associated with a wide spectrum of conditions, all characterized growth failure such as Leri-Weill dyschondrosteosis, Turner syndrome, short stature with subtle auxological and radiological findings and the so called "idiopathic short stature" (short stature with no specific findings other than growth failure).
View Article and Find Full Text PDFUnlabelled: We report the recommendations for the diagnosis, treatment, imaging evaluation and use of antibiotic prophylaxis in children with the first febrile urinary tract infection, aged 2 months to 3 years. They were prepared by a working group of the Italian Society of Pediatric Nephrology after careful review of the available literature and a consensus decision, when clear evidence was not available.
Conclusion: These recommendations are endorsed by the Italian Society of Pediatric Nephrology.
Article Synopsis
- Chronic kidney disease (CKD) can lead to end-stage renal failure in children, and while angiotensin-converting enzyme inhibitors (ACEi) are known for their protective effects in adults, their effectiveness in pediatric cases remains uncertain.
- A study using data from the ItalKid Project compared 41 children treated with ACEi for hypodysplastic CKD to 123 matched controls, measuring the decline in kidney function over time.
- Results showed that ACEi-treated patients had a 40% slower decline in creatinine clearance compared to controls, but this difference was not statistically significant, indicating the need for further research before ACEi can be recommended as a standard treatment for children with CKD.
In chronic renal failure high serum urea levels (sUrea) are correlated with the onset of uremic symptoms. Urea has generally been considered relatively non-toxic, functioning more as a surrogate for other toxic solutes; however, it has been recently reported that it can contribute to uremic toxicity. Clinically sUrea are often difficult to interpret because of the wide range of kidney functions.
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