Photodynamic inactivation of influenza virus with fullerene C60 suspension in allantoic fluid.

Background: Viruses are the most dangerous infectious contaminants of human donor blood and blood products. The purpose of the study was to investigate the virus-inactivating properties of fullerene suspension regarding influenza virus in allantoic fluid of chicken embryos.

Methods: Influenza virus was propagated in chicken embryos, water suspension of C60 fullerene was added to the allantoic fluid.

Synthesis and pharmacology of N-alkylated derivatives of the excitotoxin ibotenic acid.

Three amino-alkylated derivatives of the naturally occurring excitatory amino acid (EAA) receptor agonist ibotenic acid (Ibo) have been synthesized and tested pharmacologically. N-Methyl-Ibo (1a) and N-ethyl-Ibo (1b) were shown to be agonists at NMDA receptors (EC50 = 140 and 320 microM, respectively), though with activities considerably lower than Ibo (EC50 = 9.6 microM).

Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine.

The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats.

Excitatory action of some aspartate- and glutamate-containing dipeptides after intracerebroventricular injection in mice.

The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v.

Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.

The effects of three dipeptide analogues of N-acetylaspartylglutamate on seizures elicited by intracerebroventricular (i.c.v.