Publications by authors named "L Pinali"
Background: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with cystic fibrosis (CF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, and predictors of FEV change after treatment have yet to be defined.
Research Question: Which ventilatory parameters are involved in the heterogeneity of FEV change after 12-month ETI treatment in people with CF and advanced lung disease?
Study Design And Methods: This was a multicenter, observational, prospective cohort study at two major CF centers in Italy.
Article Synopsis
- Oncovascular surgery, which involves removing major blood vessels affected by cancer, is crucial for achieving complete removal of tumors in advanced ovarian cancer patients.
- A review of patient cases at Verona University showed that five patients had successful major vascular resections, with all having preoperative identification of vascular involvement and obtaining R0 status (no visible cancer remaining).
- The literature review found a total of 12 cases of major vessel resections in ovarian cancer, with a notable percentage experiencing postoperative complications, yet a majority remained disease-free at their last follow-up.
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in cystic fibrosis (CF), with increasing incidence in recent years. We examined the association between bacterial colonization in the sputum (MRSA with or without pseudomonas (PA)) and computed tomography (CT) scores in CF patients.
Methods: MRSA patients were divided according to PA status based on at least three consecutive sputum cultures; controls were patients without MRSA (with or without PA), matched for gender and age at CT.
Importance And Aims: The role of CT colonography (CTC) as a colorectal cancer (CRC) screening test is uncertain. The aim of our trial was to compare participation and detection rate (DR) with sigmoidoscopy (flexible sigmoidoscopy (FS)) and CTC in a screening setting.
Design Setting And Participants: We conducted two randomised clinical trials (RCTs).
Purpose: This study assessed the usefulness of magnetic resonance diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions.
Materials And Methods: Gadolinium-enhanced magnetic resonance imaging (MRI) and DWI with determination of the apparent diffusion coefficient (ADC) were performed on 78 women, each with a focal breast lesion at least 7 mm in diameter, which was studied by cytology or histology.
Results: Final diagnoses were obtained by cytology in 29 cases and histology in 49 (11 percutaneous biopsies and 38 surgical specimens).