Publications by authors named "L Pina-Camacho"
Article Synopsis
- The study investigates how early-adolescence prodromes in schizophrenia (SCZ) relate to social cognition deficits and sensorimotor impairments, comparing them to autism spectrum disorders (ASD).
- It involves four groups: ASD, SCZ with early-adolescence prodromes (under 15), SCZ with late-adolescence prodromes (over 15), and a control group, analyzing their social cognition and neurological soft signs (NSS).
- Findings indicate that SCZ with early prodromes show similar social cognition impairments as those with ASD, highlighting that age of prodrome onset plays a critical role in understanding SCZ subgroups rather than just the onset of psychosis.
Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). The aim of this article was to examine potential sex differences among first-episode schizophrenia (FES) patients and analyze sex-related predictors of two NS symptoms factors (EXP and MAP) and functional outcome.
View Article and Find Full Text PDFIdentifying risk factors for predominant negative symptoms from early stages in schizophrenia: A longitudinal and sex-specific study in first-episode schizophrenia patients.
Span J Psychiatry Ment Health
November 2023
Article Synopsis
- This study examines the prevalence of predominant negative symptoms (PNS) in first-episode schizophrenia patients, noting that these individuals have distinct clinical and functional characteristics compared to those without PNS.
- Among the 121 patients studied, 24.8% developed PNS within a year, with variations in rates between men (27.6%) and women (20%).
- Key risk factors differ by sex; for women, poor premorbid adjustment is a significant predictor, while for men, factors like verbal memory performance and motivational alterations are more telling.
Article Synopsis
- Obstetric complications (OCs) contribute to the risk of developing psychosis, but it's unclear if they do so independently from genetic factors, in combination with them, or as an indicator of inherent psychosis risk.
- A study involving 405 participants found that complications during pregnancy and abnormal fetal growth were significantly linked to higher risks of psychosis, while delivery complications showed no such association.
- Despite finding that genetic vulnerability for schizophrenia was related to psychosis, the study revealed no significant interactions between genetic risk and OCs, suggesting that the type and timing of OCs may play varying roles in influencing psychosis risk.
Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs.
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