Publications by authors named "L Pietrangelo"
Objective: This study explores whether hyaluronic acid (HA) of different molecular weights and collagen, given their role in tendon extracellular matrix maintenance, have a synergistic effect on human tendon-derived cells, with the aim to improve the treatment of tendinopathy.
Material: Human monocytes (CRL-9855™) and primary Achilles tendon-derived cells.
Treatment: The collagen/HA ratio was based on the formulation of the commercial food supplement TendoGenIAL™.
Among the numerous changes that occur in skeletal muscle during aging, the reduced regeneration potential after an injury is largely due to the impaired ability of satellite cells to proliferate and differentiate. Herein, using the freeze-fracture electron microscopy technique, we analyzed both the incidence and size of dihydropyridine receptors (DHPRs) tetrads (4 particles) in cultured myotubes from a young subject (28 years) after 9 days of differentiation and from an old subject (71 years) after 9 and 12 days of differentiation. Compared to young myotubes, at 9 days of differentiation old myotubes exhibited: i) a lower incidence and a smaller size of DHPR clusters and ii) a lower number of complete tetrads.
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- Menopause can negatively impact women's health, prompting a study on the benefits of Filme Gyno-V ovules containing tocopherol acetate for vaginal well-being.
- The research involved 50 women aged 50-70, divided into menopausal and premenopausal groups, who used the ovules for two weeks and were assessed before and after treatment.
- Results indicated significant improvement in symptoms like dryness and pain, along with positive changes in vaginal microbiota, suggesting the ovules' effectiveness for vaginal health.
Tubular aggregate myopathy (TAM) is a heritable myopathy primarily characterized by progressive muscle weakness, elevated levels of creatine kinase (CK), hypocalcemia, exercise intolerance, and the presence of tubular aggregates (TAs). Here, we generated a knock-in mouse model based on a human gain-of-function mutation which results in a severe, early-onset form of TAM, by inducing a glycine-to-serine point mutation in the ORAI1 pore (Orai1 or GS mice). By 8 months of age, GS mice exhibited significant muscle weakness, exercise intolerance, elevated CK levels, hypocalcemia, and robust TA presence.
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- Managing burn injuries is complicated due to antibiotic resistance, prompting research into new treatments using live Lactic Acid Bacteria (LAB) as an alternative.
- The study assessed the antimicrobial properties of LAB from human breast milk and their effects on immune response in a burn wound infection model.
- Results showed LAB effectively inhibited harmful bacteria, improved larval survival rates, and influenced immune gene expression, suggesting LAB could be a promising option for burn wound care while minimizing antibiotic resistance.