Publications by authors named "L Pierini"
Gravitational waves from subsolar mass inspiraling compact objects would provide almost smoking-gun evidence for primordial black holes (PBHs). We perform the first search for inspiraling planetary-mass compact objects in equal-mass and highly asymmetric mass-ratio binaries using data from the first half of the LIGO-Virgo-KAGRA third observing run. Though we do not find any significant candidates, we determine the maximum luminosity distance reachable with our search to be of O(0.
View Article and Find Full Text PDFIn this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.
View Article and Find Full Text PDFObjective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria.
Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform.
Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others.
Article Synopsis
- The study investigates compact binary coalescences with at least one component mass between 0.2 and 1.0 solar masses using data from Advanced LIGO and Advanced Virgo detectors over six months in 2019, but they found no significant gravitational wave candidates.
- The analysis leads to an upper limit on the merger rate of subsolar binaries ranging from 220 to 24,200 Gpc⁻³ yr⁻¹, based on the detected signals’ false alarm rate.
- The researchers use these limits to set new constraints on two models for subsolar-mass compact objects: primordial black holes (suggesting they make up less than 6% of dark matter) and
DNA polymerase kappa (Pol κ) has been well documented thus far for its specialized DNA synthesis activity during translesion replication, progression of replication forks through regions difficult to replicate, restart of stalled forks, and replication checkpoint efficiency. Pol κ is also required for the stabilization of stalled forks, although the mechanisms are poorly understood. In this study, we unveiled an unexpected role for Pol κ in controlling the stability and abundance of checkpoint kinase 1 (Chk1), an important actor for the replication checkpoint and fork stabilization.
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