Publications by authors named "L Pickle"
Article Synopsis
- Induced pluripotent stem cells (iPSCs) are valuable for studying diseases, discovering drugs, and regenerative medicine, but creating high-quality clinical-grade iPSCs is still challenging.
- The CTS CytoTune-iPS 2.1 kit is the first off-the-shelf solution designed for clinical and translational research, aiming to streamline the reprogramming process.
- The kit enables the consistent generation of iPSCs from various cell types, and the resulting clones are thoroughly characterized to ensure they are pluripotent, maintain genomic integrity, and are suitable for clinical use.
Background: After a period of increasing rates, lung cancer incidence is declining in the US for men and women. We investigated lung cancer rate patterns by gender, geographic location, and histologic subtype, and for total lung cancer (TLC), for the entire study period, and for 2000-2011 from 17 surveillance, epidemiology, and end results areas.
Methods: For each gender-histologic type combination, time trend plots and maps of age-adjusted rates are presented.
Background: Ratios of age-adjusted rates between a set of geographic units and the overall area are of interest to the general public and to policy stakeholders. These ratios are correlated due to two reasons-the first being that each region is a component of the overall area and hence there is an overlap between them; and the second is that there is spatial autocorrelation between the regions. Existing methods in calculating the confidence intervals of rate ratios take into account the first source of correlation.
View Article and Find Full Text PDFBackground: Urban sprawl has the potential to influence cancer mortality via direct and indirect effects on obesity, access to health services, physical activity, transportation choices and other correlates of sprawl and urbanization.
Methods: This paper presents a cross-sectional analysis of associations between urban sprawl and cancer mortality in urban and suburban counties of the United States. This ecological analysis was designed to examine whether urban sprawl is associated with total and obesity-related cancer mortality and to what extent these associations differed in different regions of the US.
Background: The current study was undertaken to evaluate the spatiotemporal projection models applied by the American Cancer Society to predict the number of new cancer cases.
Methods: Adaptations of a model that has been used since 2007 were evaluated. Modeling is conducted in 3 steps.