Publications by authors named "L Peverelli"
Introduction: COVID-19 pandemic had a great impact on outcome in SARS-CoV-2 positive patients with ischemic stroke during the first wave in Italy. Few data are available on outcome stratified by sex.
Methods: The Italian Society of Hospital Neuroscience conducted a multi-center, retrospective, observational study on neurological complications in COVID-19 patients with ischemic stroke.
Article Synopsis
- HyperCKemia is linked to neuromuscular diseases and can appear with various symptoms like cramps and weakness, prompting an investigation into its genetic causes.
- A study of 139 patients found a definite genetic diagnosis in 15.1% of cases, while 39.5% showed candidate variants, indicating a diverse genetic background.
- The research highlights genetic heterogeneity in hyperCKemia, suggesting that some cases may be caused by external factors rather than inherited genetic mutations.
Article Synopsis
- * The study examined muscle fibers from patients with truncating mutations and healthy controls to evaluate myosin presence, modifications, and functionality using various analytical methods.
- * Key findings reveal that a specific acetylated myosin variant was present in patients, linked to increased ATP demand, faster kinetics, and reduced force in muscle fibers, highlighting the impact of these mutations on myosin activity.
Objective: To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the first pandemic wave, Lombardia.
Methods: Adult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).
Results: Thirty-eight COVID19-GBS patients had a mean age of 60.