Publications by authors named "L Petraglia"
Atrial Fibrillation can be considered a geriatric syndrome for its prevalence and incidence, its impact on patients' quality of life, and Health Systems' economy. The European Society of Cardiology 2024 guidelines introduce a recommendation for maintaining vitamin K antagonist therapy over switching to direct oral anticoagulants in clinically stable elderly patients with atrial fibrillation. This article explores the implications of this indication for the geriatric clinical context.
View Article and Find Full Text PDFCardiac involvement strongly impacts prognosis in patients with Anderson-Fabry disease (AFD). All cardiac structures, such as the left ventricle and the left atrium, the aorta, the right sections, and the heart valves can be affected by morphological and functional abnormalities. Standard echocardiography has a crucial role in the characterization of AFD cardiomyopathy.
View Article and Find Full Text PDFBackground: Ischemic stroke may trigger neuroplastic changes via proliferation, migration towards the lesion, and differentiation of neuroprogenitor cells into mature neurons. Repetitive Transcranial Magnetic Stimulation (rTMS) may promote brain plasticity. This study aimed to assess rTMS's effect on post-stroke endogenous neuroplasticity by dosing plasma miRs 17~92, Netrin-1, Sema3A, and BDNF.
View Article and Find Full Text PDFArticle Synopsis
- Isolated amyloid deposition is common in stenotic aortic valves (AVs) among patients who do not have systemic or cardiac amyloidosis, with significant findings from a study of 130 patients undergoing cardiac surgery.
- In the study, amyloid was found in 37% of aortic stenosis valves, leading to higher levels of AV fibrosis and calcification, but no differences in clinical characteristics or survival rates were observed between those with and without amyloid deposition.
- The research suggests that local inflammation might contribute to amyloid deposition in AVs, highlighting its potential role in the pathophysiology of aortic stenosis despite its lack of direct clinical relevance.
Background: Futile recanalization (FR) is de fined as a poor 90-day outcome or lack of neurological improvement at 24 h despite successful recanalization in acute ischemic stroke (AIS) with large vessel occlusion (LVO) treated by mechanical throbectomy (MT). The No-reflow phenomenon (NRP) could be a possible cause of FR, but its evidence in AIS patients is scarce.
Methods: We retrospectively analyzed 185 digital subtraction angiographies (DSA) of AIS patients with anterior circulation LVO after endovascular treatment.