Publications by authors named "L Perez-Rodriguez"
Background: IgE-mediated food allergy and eosinophilic esophagitis (EoE) are diseases commonly triggered by milk. Milk-responsive CD4 T cells producing type 2 cytokines are present in both diseases, yet the clinical manifestation of disease in milk allergy (MA) and EoE are distinct.
Objective: We sought to identify differences in CD4 T cells between EoE and MA that may be responsible for distinct disease manifestations.
Article Synopsis
- Idiopathic Pulmonary Fibrosis (IPF) is a lung disease characterized by progressive scarring and currently lacks a cure, prompting the need for new therapeutic targets such as the cAMP pathway, particularly the protein Epac1.* -
- The study aimed to understand how Epac1 contributes to IPF progression by examining lung samples from IPF patients and preclinical models, alongside testing the effects of inhibiting Epac1 using a specific pharmacological agent, AM-001.* -
- Results showed that Epac1 levels were elevated in IPF tissue and fibroblasts, and inhibiting Epac1 led to reduced fibroblast proliferation and profibrotic signaling, indicating its potential role as a therapeutic target
Oxidative Challenges Do Not Impact Pheomelanin-Dependent Coloration in Male Japanese Quails.
J Exp Zool A Ecol Integr Physiol
January 2025
Article Synopsis
- Colorful traits, especially melanin-based colorations like pheomelanin, are crucial for animal communication but are less studied, particularly regarding their connection to oxidative stress in individuals.
- A study on male Japanese quails showed that pheomelanic colorations decreased after exposure to oxidative stress, but the intensity of this change was similar across different treatment groups, contradicting predictions.
- Additionally, the research found no significant effects on oxidative status indicators like glutathione levels or variations among the treatment groups, suggesting that the expected link between pheomelanin coloration and oxidative stress may not hold true.
This study investigates the effect of daily consumption of a concentrated garlic and onion extract on COVID-19 symptoms among elderly nursing home residents. Volunteers consumed a daily capsule of the concentrated powder rich in organosulfur compounds over 36 weeks during lunch. The incidence and severity of COVID-19 symptoms between the treatment and control groups were compared, along with monitoring the safety of consumption, incidence of other diseases, and medicine usage.
View Article and Find Full Text PDFExploring the evolutionary architecture of female sexual traits and their potential evolvability is important to understand their possible role as postmating sexual signals. Egg colouration has been proposed to be one of these postmating sexual signals, honestly advertising female quality in birds, especially in blue-green laying species. In this study, we used an animal model in a Bayesian framework to estimate the evolvability of multiple descriptors of blue-green egg colouration and egg size in a wild long-term monitored population of spotless starlings (Sturnus unicolor).
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