Publications by authors named "L Perez-Latorre"
Background And Aims: In response to direct-acting antivirals (DAAs) therapy, patients who experience a decrease in hepatic venous pressure gradient (HVPG) considerably reduce liver complications and have increased survival. This study aimed to assess the metabolomic changes associated with the changes in HVPG from the start of DAA therapy until 48 weeks after effective DAA therapy in patients with advanced HCV-related cirrhosis.
Methods: We carried out a multicenter longitudinal study in 31 patients with advanced hepatitis C virus (HCV)-related cirrhosis.
Altered blood microbiome in patients with HCV-related Child-Pugh class B cirrhosis.
J Infect Public Health
October 2024
Background: Altered bacterial translocation is associated with changes in hepatic function and the progression from compensated to decompensated cirrhosis. Child-Turcotte-Pugh (CTP) score is an essential indicator of liver severity. Thus, we aimed to study differences in the blood microbiome together with metabolome profile between HCV-infected patients with CTP class B (CTP-B, significant functional compromise) and patients with CTP class A (CTP-A, well-compensated cirrhosis).
View Article and Find Full Text PDFSARS-CoV-2 infection vs. vaccination during pregnancy: the placenta leads the way.
Curr Opin Infect Dis
October 2024
Purpose Of Review: To understand the characteristics and determinants of transplacental antibody transfer against SARS-CoV-2 and to compare the differences between SARS-CoV-2 infection and vaccination.
Recent Findings: The need for information during the COVID-19 pandemic and the exclusion of pregnant women from randomized clinical trials have led to a vast amount of clinical data primarily based on observational studies with diverse design and sample analyses that yield variable results. This review aims to critically and comprehensively integrate the relevant knowledge related to transplacental transfer of antibodies against SARS-CoV-2, emphasizing the differences between infection and vaccination.
Article Synopsis
- Combination antiretroviral therapy (ART) has significantly improved the health of people with HIV (PWH), yet they still experience chronic inflammation and immune activation despite effective treatment.
- A study was conducted comparing the plasma metabolomic profiles of 17 PWH on long-term ART with 19 healthy controls, using advanced statistical methods to analyze the data.
- Results showed that while there were no major differences in metabolomic profiles between the groups, three significant metabolites related to inflammation were identified in PWH, indicating some residual metabolic changes linked to inflammation even after effective treatment.
Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of BSIs in a 12-year period, including the COVID-19 pandemic.
Methods: All blood cultures received in the laboratory of a tertiary general hospital between 2010 and 2021 were analyzed.