Should we Cryopreserve Allogenic Hematopoietic Stem Cell Grafts?

Background/aim: Cryopreservation of allogeneic hematopoietic cells can be an necessary step in the preparation of a graft for transplantation. The purpose of this study was to evaluate the safety of cryopreservation of allogeneic hematopoietic cells and the clinical outcomes of patients who received a cryopreserved transplant.

Patients And Methods: The study included data from a comparative analysis conducted on a group of 100 patients diagnosed with acute myeloid leukemia who received cryopreserved (50 patients) and fresh (50 patients) transplants.

Herbivory legacy modifies leaf economic spectrum and drought tolerance in two tree species.

The concurring effect of herbivory by wild ungulates and drought events is experiencing a notable increase in Mediterranean and temperate forests. While many studies have addressed the influence of drought on plant susceptibility to herbivory, it appears crucial to comprehend the impact of prolonged browsing on the physiological response of plants to increasing water deficit. To this end, we analyzed the effect of long-term recurrent herbivory by ungulates on physiological, biochemical, anatomical and morphological variables of Ilex aquifolium and Fagus sylvatica saplings during the growing seasons of 2018 and 2019 in a mixed sub-Mediterranean forest.

Tuberculosis after hematopoietic cell transplantation: retrospective study on behalf of the Infectious Diseases Working Party of the EBMT.

Tuberculosis (TB) is rare following hematopoietic cell transplantation (HCT). In this multinational retrospective study, we report the frequency, characteristics, and outcome of TB following HCT performed during 2000-2019. Fifty-two patients (35 (67%) males, 15 (29%) children) from 24 centers developed TB following allogeneic (n = 47) or autologous (n = 5) HCT; with the relative frequency of 0.

Microcontact printing of lectin self-assembled monolayers for arbovirus detection.

Arboviruses significantly burden public health in Brazil, constituting a constant challenge for health authorities. The diagnosis and, consequently, clinical management and the reporting of arbovirus infections in regions where multiple arboviruses coexist are complex processes. Herein, we report the development of a new electrochemical biosensor based on Concanavalin A (ConA) to identify carbohydrate patterns in the viral structure of Dengue 3 (DENV-3), Zika (ZIKV) and Chikungunya (CHIKV) viruses.