Liver Xenotransplantation: A Path to Clinical Reality.

Liver xenotransplantation has emerged as a potential solution to the shortage of deceased human donor organs and is now becoming a reality due to recent developments in genetic engineering and immunosuppressive therapy. Early efforts using non-human primates and genetically modified pigs faced significant challenges such as thrombocytopenia and graft rejection. Understanding the mechanism behind those challenges and using novel genetically engineered pigs enabled researchers to overcome some of the hurdles, but more research is needed.

Younger adults may be faster at making semantic predictions, but older adults are more efficient.

While there is strong evidence that younger adults use contextual information to generate semantic predictions, findings from older adults are less clear. Age affects cognition in a variety of different ways that may impact prediction mechanisms; while the efficiency of memory systems and processing speed decrease, life experience leads to complementary increases in vocabulary size, real-world knowledge, and even inhibitory control. Using the visual world paradigm, we tested prediction in younger ( = 30, between 18 and 35 years of age) and older adults ( = 30, between 53 and 78 years of age).

Effectiveness of Body Remodeling and Cellulite Appearance Improvement Treatments in the Thighs Using Symmed Radiofrequency Device.

Background: Aging associated with the passage of time causes alterations in subcutaneous tissues and the overall appearance of the skin that generate aesthetic unconformities in people. Within the wide range of available techniques on the market, radiofrequency (RF) diathermy has emerged as one of the most used non-invasive methods to combat them.

Objective: This clinical trial aims to determine and quantify the effectiveness and safety of the high-frequency RF-based device Symmed (Termosalud Inc.

Characterizing astrocyte-mediated neurovascular coupling by combining optogenetics and biophysical modeling.

Vasoactive signaling from astrocytes is an important contributor to the neurovascular coupling (NVC), which aims at providing energy to neurons during brain activation by increasing blood perfusion in the surrounding vasculature. Pharmacological manipulations have been previously combined with experimental techniques (e.g.