Publications by authors named "L Pemberton"

Plans are formulated and refined throughout the period leading up to their execution, ensuring that the appropriate behaviors are enacted at the appropriate times. While existing evidence suggests that memory circuits convey the passage of time through diverse neuronal responses, it remains unclear whether the neural circuits involved in planning exhibit analogous temporal dynamics. Using publicly available data, we analyzed how activity in the mouse frontal motor cortex evolves during motor planning.

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Background: Restrictive practices (RPs) are defined by measures linked to physical and chemical restraints to reduce the movement or control behaviours during any emergency. Seclusion is an equal part of RPs intended to isolate and reduce the sensory stimulation to safeguard the patient and those within the vicinity. Using interventions by way of virtual reality (VR) could assist with reducing the need for RPs as it could help reduce anxiety or agitation by way of placing users into realistic and immersive environments.

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Background: Enhancing the quality of therapeutic engagement between nurse and service user is related to positive impact on care, safety, and recovery outcomes. Achieving improved therapeutic engagement remains challenging in the acute mental health inpatient setting, characterised by complex social processes and contextual features that constrain behaviour change. The Therapeutic Engagement Questionnaire is an evidence-based tool co-produced with service users and nurses to improve therapeutic engagement.

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Article Synopsis
  • Carboplatin monotherapy is considered by some clinicians for advanced castrate-resistant prostate cancer (CRPC) after other treatments have failed, even though solid evidence for its effectiveness is limited.
  • This study retrospectively analyzed the use of carboplatin in Australian patients with refractory prostate cancer, focusing on efficacy, toxicity, and demographic data.
  • Results showed that while a small percentage of patients had a notable PSA response, overall survival was limited, and treatment was associated with mild toxicity, leading some patients to require dose adjustments or discontinue treatment.
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