Publications by authors named "L Peltier"
Optimal decision-making depends on interconnected frontal brain regions, enabling animals to adapt decisions based on internal states, experiences, and contexts. The secondary motor cortex (M2) is key in adaptive behaviors in expert rodents, particularly in encoding decision values guiding complex probabilistic tasks. However, its role in deterministic tasks during initial learning remains uncertain.
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- Developing advanced cell therapy products involves defining key concepts like mechanism of action (MOA), potency, and efficacy, which can be challenging but is crucial for success.
- The text introduces a logical framework that aligns with regulatory guidelines and draws on insights from 27 FDA-approved cell therapy products to better understand these concepts.
- It highlights the complexity of correlating potency test results with clinical outcomes, discusses common misconceptions, and emphasizes the need for effective communication among developers throughout the product development process.
Rare cause of life-threatening hypercalcemia in an infant: a case report.
Ann Biol Clin (Paris)
September 2022
Background: 25-Hydroxyvitamin D 24-hydroxylase (CYP24A1) deficiency is a rare cause of autosomal recessive infantile hypercalcemia due to vitamine D hypersensitivity.
Case Presentation: We report the case of a 2-year-old boy who presented with severe hypercalcemia-hypercalciuria and a bilateral nephrocalcinosis. Laboratory investigations detected a collapsed parathormone and a highly elevated 1α,25-dihydroxycholecalciferol along with an increased phosphate excretion (hypophosphatemia and hyperphosphaturia).
Introduction: Myositis are systemic diseases, in which heart damage is possible. Cardiac troponin T is often found to be defective to detect cardiac involvement.
Observation: We report cases of two patients with a myositis.