Publications by authors named "L Pelosi"
It is currently unclear how Pseudomonadota, a phylum that originated around the time of the Great Oxidation Event, became one of the most abundant and diverse bacterial phyla on Earth, with metabolically versatile members colonizing a wide range of environments with different O2 concentrations. Here, we address this question by studying isoprenoid quinones, which are central components of energy metabolism covering a wide range of redox potentials. We demonstrate that a dynamic repertoire of quinone biosynthetic pathways accompanied the diversification of Pseudomonadota.
View Article and Find Full Text PDFNerve ultrasound as a screening tool for inherited sensory neuronopathy.
J Peripher Nerv Syst
December 2024
Article Synopsis
- The study analyzed lower limb nerve ultrasound measurements to differentiate between inherited neuronopathy, inherited axonopathy, and acquired axonopathy in patients.
- Researchers compared nerve sizes in 34 healthy controls with three patient groups, finding significant size variations particularly in the tibial and sural nerves.
- Results indicated that inherited conditions (CANVAS and CMT2) had smaller nerve sizes compared to the acquired condition, suggesting ultrasound can help in diagnosing these neurological diseases more effectively.
All biological hydroxylation reactions are thought to derive the oxygen atom from one of three inorganic oxygen donors, O, HO or HO. Here, we have identified the organic compound prephenate as the oxygen donor for the three hydroxylation steps of the O-independent biosynthetic pathway of ubiquinone, a widely distributed lipid coenzyme. Prephenate is an intermediate in the aromatic amino acid pathway and genetic experiments showed that it is essential for ubiquinone biosynthesis in under anaerobic conditions.
View Article and Find Full Text PDF