Publications by authors named "L Pellizzari"
Article Synopsis
- Head and Neck Squamous Cell Cancer (HNSCC) is a significant health concern, ranking sixth among global cancers, with a pressing need for new therapies and biomarkers due to slow advancements in treatment personalization.!* -
- This study analyzed the somatic mutations in 15 specific genes related to HNSCC in a high-incidence area of Italy, finding unique mutation patterns that may have prognostic implications, particularly in the hypopharyngeal region.!* -
- The research revealed that while certain mutations indicate poorer prognosis, they currently lack sufficient evidence to be used as predictive biomarkers, highlighting the necessity for further studies to improve treatment options for HNSCC patients.!*
Background: Antibiotic stewardship (AS) is a cornerstone of the fight against antimicrobial resistance; however, evidence on the best practice to improve antibiotic prescription in various hospital settings is still scarce. This study aimed to measure the efficacy of a non-restrictive AS intervention in the internal medicine area of a tertiary-care hospital across a 3-year period.
Methods: The intervention comprised a 3-month 'intensive phase' based on education and guidelines provision, followed by 9 months of audits and feedback activities.
Objectives: The aim of this study was to evaluate the activity of anti-activated factor X (anti-Xa) in patients with different degrees of chronic renal failure (CRF), treated with therapeutic doses of low molecular weight heparin.
Design: This prospective study evaluated the effect of age, renal function, BMI, gender, in determining the efficacy and safety of treatment with enoxaparin, evaluated by assessing the anti-Xa. The therapeutic anticoagulant range was set between 0.
The homeodomain (HD) is a 60 amino acid-long DNA-binding domain. A large fraction of HDs binds with high affinity sequences containing the 5'-TAAT-3' core motif. However, NK-2 class HDs recognizes sequences containing the 5'-CAAG-3' core motif.
View Article and Find Full Text PDFPurpose: PAX6 mutations cause aniridia as well as other various congenital eye abnormalities. Aniridia can be due to both point mutations and chromosomal deletions/rearrangements. Therefore, a complete search for PAX6 gene alterations in aniridia subjects requires a technically complex approach involving the comprehension of fluorescence in situ hybridization (FISH) analysis.
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