Publications by authors named "L Pelegrin"
Article Synopsis
- The article discusses corrections to research findings initially published.
- It emphasizes the importance of accuracy in scientific communication.
- This correction aims to ensure that readers are aware of any significant changes to the original data and conclusions.
Article Synopsis
- Non-infectious inflammatory ocular diseases can be challenging to diagnose and manage, often requiring systemic immunosuppressive therapy; JAK inhibitors may offer a new treatment approach.
- A study with 12 patients showed that systemic diseases were present in 67% of cases, and various JAK inhibitors were administered, with an average treatment duration of 8.6 months.
- Results indicated complete ocular disease control in all patients after treatment, with a significant reduction in the incidence of ocular flares, confirming the efficacy and safety of JAK inhibitors for these conditions.
Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases.
Front Ophthalmol (Lausanne)
February 2024
Autoinflammatory diseases include disorders with a genetic cause and also complex syndromes associated to polygenic or multifactorial factors. Eye involvement is present in many of them, with different extent and severity. The present review covers ophthalmological lesions in the most prevalent monogenic autoinflammatory diseases, including FMF (familial Mediterranean fever), TRAPS (TNF receptor-associated periodic syndrome), CAPS (cryopyrin-associated periodic syndromes), Blau syndrome, DADA2 (deficiency of adenosine deaminase 2), DITRA (deficiency of the interleukin-36 receptor antagonist), other monogenic disorders, including several ubiquitinopathies, interferonopathies, and the recently described ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome, and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
View Article and Find Full Text PDFPurpose: Hydroxychloroquine is currently recommended for the treatment of systemic lupus erythematosus (SLE), but it can cause irreversible retinal toxicity. This study aimed to identify factors associated with early hydroxychloroquine-induced retinal toxicity in patients with SLE from a single centre for 20 years.
Methods: SLE patients diagnosed between 1998 and 2017 and followed up for at least 1 year were included.
Article Synopsis
- The study focuses on defining and characterizing the disease phenotypes of adult patients with undifferentiated autoinflammatory diseases who experienced recurrent fevers and inflammatory issues, with inconclusive genetic tests.
- It analyzed 134 patients from a reference center over several years, identifying five phenotypes, including a significant number meeting the criteria for PFAPA syndrome and several with varying predominant symptoms.
- The treatment analysis found that medications like prednisone, colchicine, and anakinra were commonly prescribed, with effectiveness rates of 41.3%, 40.2%, and 58.3% for complete responses, respectively, with specific preferences for medications based on patient phenotype.