Publications by authors named "L Pazourek"

Hand and foot osteosarcoma represents ~1% of all diagnosed cases of osteosarcoma. The rarity of osteosarcoma of the hand and foot leads to frequent misdiagnosis, delayed diagnosis or incorrect treatments, which can lead to fatal consequences. Typically, salvaging the affected limb is the treatment of choice, and with the use of chemotherapy, 60-65% of patients with osteosarcoma can be treated without amputation.

View Article and Find Full Text PDF
Article Synopsis
  • Myxofibrosarcoma is a type of cancer that tends to grow infiltratively, making it hard to achieve clear surgical margins, which leads to a high chance of local recurrence.
  • In a study of 111 patients, researchers found a 5-year overall survival rate of 65.5%, with age over 65, larger tumor size, and higher tumor grade negatively impacting this rate.
  • While clear surgical margins positively affect recurrence-free survival, a margin of just 2 mm may not be enough, indicating that wider margins could be necessary to lower the risk of recurrence.
View Article and Find Full Text PDF

Background And Objectives: Curettage is the removal of a tumor from the bone while preserving the surrounding healthy cortical bone, and is associated with higher rates of local recurrence. To lower these rates, curettage should be combined with local adjuvants, although their use is associated with damage to nearby healthy bone.

Objective: The purpose of this analysis is to determine the effect of local adjuvants on cortical porcine bone by using micro-computed tomography (micro-CT) along with histological and mechanical examination.

View Article and Find Full Text PDF

Background: Total knee arthroplasty (TKA) with all-polyethylene tibial (APT) components has shown comparable survivorship and clinical outcomes to that with metal-backed tibial (MBT). Although MBT is more frequently implanted, APT equivalents are considered a low-cost variant for elderly patients. A biomechanical analysis was assumed to be suitable to compare the response of the periprosthetic tibia after implantation of TKA NexGen APT and MBT equivalent.

View Article and Find Full Text PDF