Publications by authors named "L Payne"

Objectives: To determine ADHD research priorities from the perspective of ADHD professionals internationally.

Method: A two-stage modified Delphi design was used. In Stage 1 (qualitative), participants listed research questions relating to ADHD that they perceived to be most important ( = 132).

View Article and Find Full Text PDF

Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been discovered, each containing predicted membrane-embedded ZorAB complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems. Here, we investigate the molecular basis of Zorya defense using cryo-electron microscopy, mutagenesis, fluorescence microscopy, proteomics, and functional studies.

View Article and Find Full Text PDF
Article Synopsis
  • - Approximately 14% of older adults in the UK are at risk of malnutrition, and screening in primary care could improve their quality of life and reduce healthcare use.
  • - The study developed an intervention (screen and treat protocol) to help primary care practitioners identify and support at-risk older adults and included interviews to gather insights from both practitioners and patients.
  • - Key findings reveal that while patients often resist advice about malnutrition, they appreciate nutritional support; meanwhile, practitioners face logistical challenges and varying levels of engagement and understanding regarding the intervention’s goals.
View Article and Find Full Text PDF
Article Synopsis
  • The review aimed to summarize factors influencing the use of oral nutritional supplements (ONS) among patients facing disease-related malnutrition, using a search of various databases for relevant studies published since 2000.
  • From over 21,000 articles screened, 171 were included, highlighting two main patient groups: those with malignancies and older adults, resulting in the identification of 59 barriers and facilitators impacting ONS adherence.
  • The findings suggest that patient health, motivation, product satisfaction, and healthcare support play significant roles, indicating the need for a comprehensive approach to improve adherence and more research on effective strategies.
View Article and Find Full Text PDF

The study of 3D magnetic nanostructures has uncovered rich phenomena including the stabilization of topological spin textures using nanoscale curvature, controlled spin-wave emission, and novel ground states enabled by collective frustrated interactions. From a technological perspective, 3D nanostructures offer routes to ultrahigh density data storage, massive interconnectivity within neuromorphic devices, as well as mechanical induction of stem cell differentiation. However, the fabrication of 3D nanomagnetic systems with feature sizes down to 10 nm poses a significant challenge.

View Article and Find Full Text PDF