Publications by authors named "L Patrick Schenck"
A co-processed active pharmaceutical ingredient (CP API) is the combination of an active pharmaceutical ingredient (API) with non-active component(s). This technology has been demonstrated to offer numerous benefits, including but not limited to improved API properties and stability. The infrastructure requirements are such that the manufacture of a CP API is typically best suited for an API facility.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines how different preparation methods (milling vs. precipitation) of micron-sized posaconazole crystals affect their pharmaceutical properties, particularly their dissolution performance.
- - To avoid issues from pressure-induced changes, researchers used powder dissolution instead of the typical method that compresses powders, but faced challenges due to the low wettability of the micronized powders.
- - By pre-treating the powders with a surfactant in an aqueous solution, the study showed that even with the formation of hydrates, the differing dissolution rates provide insight into how the methods of drug preparation affect their effectiveness in the body.
Article Synopsis
- Amorphous solid dispersions (ASDs) face challenges with low drug loading due to hydrophobic drugs needing more polymer for stability and release.
- The study investigated the effects of modifying high drug loading ASDs' surfaces with additional excipients to enhance drug release and wettability, using grazoprevir and hypromellose acetate succinate as examples.
- Results showed that while surface modifications improved wettability, they did not consistently lead to better drug release, indicating that wettability significantly influences the performance of these drug formulations.
Hashimoto's encephalopathy (HE), a rare immune-mediated disorder, manifests as altered mental state, cognitive and psychological dysfunction, seizures, and myoclonus. Little is known, however, about the neuropsychological profiles of individuals with HE due to the sparse amount of research. This report overviews HE, summarizes findings from available published neuropsychological evaluations, and details neuropsychological examinations of a 57-year-old White woman with a confirmed HE diagnosis evidencing persistent neuropsychological impairment at two discrete timepoints.
View Article and Find Full Text PDFArticle Synopsis
- - Crystalline active pharmaceutical ingredients (APIs) can show differences in their surface characteristics due to how they're processed, like crystallization or milling, which is important for predicting drug performance.
- - The study focuses on Odanacatib samples made by different methods that all meet size requirements for similar drug performance, emphasizing the need to understand surface properties like chemistry and wettability.
- - Researchers used various advanced techniques (like IGC, BET, contact angle measurements, and XPS) to analyze how processing affects surface properties, explaining variations in the bulk properties of the powders.