Publications by authors named "L Pasin"
Background: Limited data existed on the burden of coronavirus disease 2019 (COVID-19) renal complications and the outcomes of the most critical patients who required kidney replacement therapy (KRT) during intensive care unit (ICU) stay. We aimed to describe mortality and renal function at 90 days in patients admitted for COVID-19 and KRT.
Methods: A retrospective cohort study of critically ill patients admitted for COVID-19 and requiring KRT from March 2020 to January 2022 was conducted in an Italian ICU from a tertiary care hospital.
Article Synopsis
- Septic shock is a critical condition in ICUs with a high mortality risk (up to 40% in 28 days) that typically requires antibiotics, organ support, and sometimes surgery.
- The EROICASS study will evaluate how extracorporeal blood purification therapies (EBPT) and sequential extracorporeal therapy in sepsis (SETS) can improve patient outcomes and potentially lower 90-day mortality in septic shock patients in Italy.
- This multicenter observational study will gather data on patient demographics, clinical parameters, and treatment outcomes to better understand the effectiveness of EBPT and SETS in managing septic shock.
BACKGROUND: Glucocorticoids reduce mortality in hospitalized patients with severe and critical coronavirus disease 2019 (Covid-19), although a possible harm was documented in patients with Covid-19 not requiring oxygen. METHODS: We searched Embase, BioMed Central, medRxiv, bioRxiv, PubMed, and the Cochrane Central Register of Controlled Trials for any randomized trial or matched study ever performed on adult patients with Covid-19 not receiving oxygen therapy treated with intravenous or oral glucocorticoids versus any comparator (standard therapy or placebo); there were no restrictions on dose or time of administration. The primary end point was all-cause mortality at the longest available follow-up.
View Article and Find Full Text PDFImportance: Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermittent administration, continuous administration of meropenem may improve clinical outcomes.
View Article and Find Full Text PDFObjectives: To clarify the influence of lower tidal volume (4-7 mL/kg) compared with higher tidal volume (8-15 mL/kg) during one-lung ventilation (OLV) on gas exchange and postoperative clinical outcome.
Design: Meta-analysis of randomized trials.
Setting: Thoracic surgery.