Publications by authors named "L Parodi"
Background: Post-traumatic stress disorder (PTSD) and depression are common after mild traumatic brain injury (mTBI), but their biological drivers are uncertain. We therefore explored whether polygenic risk scores (PRS) derived for PTSD and major depressive disorder (MDD) are associated with the development of cognate TBI-related phenotypes.
Methods: Meta-analyses were conducted using data from two multicenter, prospective observational cohort studies of patients with mTBI: the CENTER-TBI study (ClinicalTrials.
[This corrects the article DOI: 10.3389/fpsyt.2024.
View Article and Find Full Text PDFBackground And Objectives: The 21-point Brain Care Score (BCS) is an index that ranks behaviors and clinical measurements with the aim of encouraging lifestyle adjustments to lower the incidence of age-related brain disease, including stroke, late-life depression (LLD), and dementia. A higher BCS at baseline is associated with a lower risk of these outcomes. We aimed to investigate whether the associations between BCS and stroke, LLD, and dementia risks are independent of genetic predisposition for these conditions and quantify the effect of healthy lifestyle across genetic risk distributions for these outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Traumatic brain injury (TBI) is a big problem worldwide, causing many deaths and disabilities, and there aren't great treatments to help recovery.
- Researchers studied whether TBI shares similar causes with other brain conditions, like Alzheimer's and schizophrenia, to find new treatment ideas.
- They found specific brain pathways related to TBI recovery that might also be important for those other conditions, especially pathways dealing with important brain chemicals like serotonin and acetylcholine.