Publications by authors named "L Parmegiani"
In recent years, the relationship between the microbiota and various aspects of health has become a focal point of scientific investigation. Although the most studied microbiota concern the gastrointestinal tract, recently, the interest has also been extended to other body districts. Female genital tract dysbiosis and its possible impact on pathologies such as endometriosis, polycystic ovary syndrome (PCOS), pelvic inflammatory disease (PID), and gynecological cancers have been unveiled.
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- Increased sperm DNA fragmentation (SDF) negatively affects fertility, leading to lower pregnancy and delivery rates in both natural conception and assisted reproduction methods like intrauterine insemination and in-vitro fertilization.
- Although high SDF does not impact fertilization or pregnancy rates with intracytoplasmic sperm injection (ICSI), it is associated with poorer embryo quality and a higher likelihood of miscarriage.
- The article reviews various sperm selection techniques aimed at improving DNA quality for assisted reproductive technology, discussing their principles, benefits, and limitations.
Article Synopsis
- Intracytoplasmic sperm injection (ICSI) was originally developed to address severe male infertility issues that conventional in-vitro fertilization (cIVF) could not solve, but it is increasingly being used for other infertility cases.
- Various non-male factor reasons for using ICSI include previous failed fertilizations, poor-quality or few oocytes, advanced maternal age, preimplantation genetic testing, and unexplained infertility.
- Despite the growing popularity of ICSI, there is limited data to support better outcomes compared to cIVF, and it's important to consider factors such as fertilization failure risk, procedure costs, and associated risks when choosing between the two techniques.
Medical Assisted Reproduction proved its efficacy to treat the vast majority forms of infertility. One of the key procedures in this treatment is the selection and transfer of the embryo with the highest developmental potential. To assess this potential, clinical embryologists routinely work with static images (morphological assessment) or short video sequences (time-lapse annotation).
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