Publications by authors named "L Parent"
Objective: Stereotactic body radiation therapy (SBRT) is a therapeutic option in the guidelines for liver primaries after standard strategies like surgery or thermoablation have failed. To assess its efficacy and safety, we reviewed all patients treated by SBRT for a hepatocellular carcinoma (HCC) over a six-year period.
Methods And Materials: The study included all patients treated by SBRT for HCC between April 2015 and November 2021 in the University Cancer Institute at Toulouse-Oncopole.
Article Synopsis
- Electron radiotherapy is preferred for treating superficial lesions due to its effectiveness at surface levels, but its complexity has led to a decline in use for many conditions, replaced by advanced techniques like intensity-modulated radiotherapy.
- Though modern photon therapies are often chosen, they still fall short for certain specific conditions where electron therapy, including total skin irradiation and some pediatric treatments, remains superior.
- The development of flash therapy, which offers high doses in a short time, shows promise with fewer side effects, indicating potential for new applications and a renewed interest in electron radiotherapy in specialized clinical settings.
Background: The endocannabinoid system and its extension, the endocannabinoidome (eCBome), are involved in numerous biological processes, notably energy homeostasis, across virtually all tissues. While the circulating eCBome mediator profile is associated with dietary intakes and metabolic status, an important knowledge gap resides in the identification of the precise determinants of these mediators in the gut lumen. We aimed at establishing the profile of eCBome mediators in human feces and investigating their association with circulating eCBome mediators, dietary intakes, metabolic status and gut microbiota composition.
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- The study examines the relationship between ACE inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and kidney health in patients with long COVID, focusing on risks for acute kidney injury (AKI), chronic kidney disease (CKD), and all-cause mortality.
- The research analyzed data from over 18,000 long COVID patients and found that ACEI/ARB use did not heighten the risk of AKI or CKD, but there was a protective effect on overall mortality among non-long COVID patients using these medications.
- Long COVID itself was linked to increased risks of CKD and mortality, highlighting the need for further understanding of kidney health in these patients.
Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of retroviral Gag proteins that localize to the cytoplasm or plasma membrane. Given that several full-length Gag proteins have been found in the nucleus, identifying the Gag-nuclear interactome has high potential for novel findings involving previously unknown host processes.
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