[Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome].

Unlabelled: The alverina citrate and simethicone combination (ACS-Meteospazmil) is used for irritable bowel syndrome (IBS) for almost 20 years, but the supporting scientific evidence for efficacy is limited.

Objective: to evaluate the effectiveness of ACS in patients with abdominal pain and discomfort at IBS.

Methods: In a double-blind, randomized, placebo-controlled study enrolled 412 patients with IBS conform to Rome criteria III.