Publications by authors named "L Pappas"
Article Synopsis
- The study analyzes the genomic differences between early-stage (1-3) and late-stage (IV) colorectal cancer (CRC), finding that early-stage patients show unique genomic alterations, particularly higher rates of microsatellite instability (MSI) and tumor mutational burden (TMB).
- Data was collected from over 4,700 patients through a clinico-genomic database, revealing that 546 early-stage patients experienced recurrence within one year, often with different genomic profiles compared to later-stage patients.
- The findings suggest that comprehensive genomic profiling (CGP) can identify distinct characteristics in early-stage CRC patients and enhance their access to targeted therapies, which are more frequently administered when CGP is conducted prior to first-line treatment.
Article Synopsis
- Biliary tract cancers show strong resistance to treatments, and effective therapies for these advanced cases are currently limited.
- A clinical trial combined DKN-01 and nivolumab to see if they could help patients with advanced biliary tract cancer, but no positive results were found.
- Researchers analyzed tissue samples to identify different cell types that contribute to the cancer's resistance, discovering new immune and malignant cell states that could inform future treatment strategies.
Background: Coronary computed tomography angiography (CCTA) in patients with post-coronary artery bypass graft (CABG) has a high diagnostic accuracy for visualization of grafts. Invasive coronary angiography (ICA) in patients with CABG is associated with increased procedural time, contrast agent administration, radiation exposure, and complications, compared with non-CABG patients. The aim of this multicenter, randomized controlled trial was to compare the strategy of CCTA-guided ICA versus classic ICA in patients with prior CABG.
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