Publications by authors named "L Palomo"
Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .
View Article and Find Full Text PDFArticle Synopsis
- Mutations commonly associated with acute myeloid leukemia (AML) were studied in 127 patients with chronic myelomonocytic leukemia (CMML), revealing varying prevalence rates like CEBPA (7), FLT3 (8), IDH1 (12), IDH2 (26), and NPM1 (11).
- CMML patients with CEBPA, FLT3, and/or NPM1 mutations showed more severe symptoms and higher risk characteristics, indicating they were more frequently linked to the myeloproliferative subtype (MP-CMML).
- The study suggests that these mutations should be included in CMML prognostic models and advocates for treating these patients with AML-type therapies due to their poor
Portable Acceleration of CMS Computing Workflows with Coprocessors as a Service.
Comput Softw Big Sci
September 2024
Article Synopsis
- Demand for computing power in major scientific experiments, like the CMS at CERN, is expected to significantly increase over the coming decades.
- The implementation of coprocessors, particularly GPUs, in data processing workflows can enhance performance and efficiency, especially for machine learning tasks.
- The Services for Optimized Network Inference on Coprocessors (SONIC) approach allows for improved use of coprocessors, demonstrating successful integration and acceleration of workflows across various environments without sacrificing throughput.
Article Synopsis
- Mutations in the TP53 gene, especially multihit alterations, are linked to worse clinical outcomes in patients with myelodysplastic syndrome (MDS).
- This study analyzed TP53 abnormalities in 682 patients with MDS who had an isolated deletion of chromosome 5 (MDS-del(5q)), revealing that 24% had multihit mutations, indicating a greater risk for leukemic transformation.
- The study found that the effect of monoallelic mutations varies with the variant allele frequency (VAF); lower VAF (<20%) behaved like wild-type TP53, while higher VAF (≥20%) showed outcomes similar to multihit mutations, highlighting the need for careful consideration of TP53 status in
Introduction: Chronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) with ring sideroblasts (RS) or mutation (MDS-RS/) differ in many clinical features, but share others, such as anemia. RS and mutation can also be found in CMML.
Methods: We compared CMML with and without RS/ and MDS-RS/ considering the criteria established by the 2022 World Health Organization classification.