Publications by authors named "L Pageler"
EFFECT OF REOPENING ORDERS ON COVID-19 HOSPITALIZATIONS IN THE US.
AMIA Jt Summits Transl Sci Proc
September 2021
Shelter in place (SIP) orders were instituted by states to alleviate the impact of the COVID-19 pandemic. However, states proceeded to reopen as SIPs were noted to be hurting the economy. We evaluated whether these reopenings affected COVID-19 hospitalizations.
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- The study aimed to evaluate the effectiveness of prednisone in treating withdrawal headaches for patients suffering from medication overuse headache (MOH).
- 96 patients with MOH were randomly assigned to receive either 100 mg of prednisone or a placebo for 5 days, while their withdrawal headaches and medication use were monitored for 14 days.
- Results showed that prednisone did not lessen the severity or duration of withdrawal headaches, but it did reduce the need for additional pain relief medication in the first 5 days.
Cluster headache is a rare primary neurovascular headache and a severe pain condition with unilateral headache over 15-180 minutes and concomitant unilateral autonomic symptoms. The detailed pathophysiology of the condition is still unclear. Only a few evidence-based therapeutic options for acute therapy and the preventive management of the disease are available.
View Article and Find Full Text PDFObjective: The aim of this study was to determine whether frovatriptan would show efficacy in short term prophylactic treatment of episodic cluster headache (ECH) in comparison to placebo.
Background: The 5-hydroxytryptamine(1B/d) (5-HT(1B/d) )-agonists naratriptan, eletriptan, and frovatriptan have been shown to reduce the frequency of ECH. So far, no double-blind placebo-controlled trials have investigated the potential prophylactic effects of 5-HT(1B/d) -agonists in ECH.
Objective: This analysis evaluates and ranks efficacy endpoints often used in headache trials concerning their clinical relevance in relation to the patient-related criterion "global assessment of overall efficacy" based on data gained in a large trial investigating different over-the-counter drugs in the treatment of headache.
Background: The original study showed a significant superiority of the fixed combination of acetylsalicylic acid+paracetamol+caffeine over the combination without caffeine, the single preparations, and placebo in the treatment of headache.
Methods: For 1734 patients included in the efficacy analysis we investigated the correlation of patient's global efficacy assessment with the endpoints "time to 50% pain relief" (primary endpoint), "time to be pain-free," pain intensity difference, sum of pain intensity difference, and extent of impairment of daily activities.