Publications by authors named "L Paduraru"
An Extensive Review on Imaging Diagnosis Methods in Takotsubo Syndrome.
Rev Cardiovasc Med
October 2023
Takotsubo Syndrome (TS) is an acute, reversible cardiac dysfunction, with complex, not entirely understood pathophysiology and heterogeneous clinical picture. Imaging methods each have a crucial role in the diagnosis, in-hospital management, short term and long term follow up. Coronary angiography needs to be performed, especially in the setting of a suspected acute coronary syndrome, in order to rule out coronary artery disease.
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- - Congenital hyperinsulinism (CHI) is a rare disorder primarily affecting glucose metabolism, leading to severe hypoglycemia, especially in newborns and young children; it often results from mutations in genes related to ATP-sensitive potassium channels.
- - In two case studies, distinct genetic mutations in patients with early-onset hyperinsulinemic hypoglycemia showed varying clinical presentations: one with a severe diffuse form linked to a homozygous mutation, and the other with a focal form linked to a heterozygous mutation.
- - The importance of molecular genetic testing is highlighted for diagnosing and managing CHI, as it can guide treatment options and emphasize the need for genetic counseling for affected families.
Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study.
Children (Basel)
January 2024
(1) Background: Neonatal early-onset sepsis (EOS) is associated with important mortality and morbidity. The aims of this study were to evaluate the association between serum and hematological biomarkers with early onset neonatal sepsis in a cohort of patients with prolonged rupture of membranes (PROM) and to calculate their diagnostic accuracy. (2) Methods: A retrospective cohort study was conducted on 1355 newborns with PROM admitted between January 2017 and March 2020, who were divided into two groups: group A, with PROM ≥ 18 h, and group B, with ROM < 18 h.
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- This review focuses on secondary diabetes mellitus, an often-overlooked topic, identifying key endocrinopathies that lead to elevated blood sugar levels.
- It describes conditions like acromegaly, Cushing's syndrome, and others, explaining how hormonal imbalances affect insulin function and can lead to diabetes.
- The study emphasizes the need for awareness and screening in endocrine diseases to tailor treatment and reduce complications, especially cardiovascular risks associated with secondary diabetes.
Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies.
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